منابع مشابه
Prognostic significance and targeting of HER family in colorectal cancer.
Colorectal cancer is one of the leading causes of cancer deaths. At present, anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) cetuximab and panitumumab and anti-vascular endothelial growth factor (VEGF) mAb bevacizumab have been incorporated into treatment paradigms for patients with refractory metastatic colorectal cancer. However, many patients simply do not respond t...
متن کاملMulticore Processing and ARTEMIS
Tiberiu Seceleanu (University of Turku, Turku Centre for Computer Science, Finland) Hannu Tenhunen (University of Turku, Turku Centre for Computer Science, Finland) Ahmed Jerraya (TIMA, France) Axel Jantsch (Royal Institute of Technology, Sweden) Georgi Kuzmanov (Delft University of Technology, The Netherlands) Kees Goosens (NXP, The Netherlands) Thierry Collette (CEA LIST, France) Bernard Cand...
متن کاملThe ErbB/HER family of protein-tyrosine kinases and cancer.
The human epidermal growth factor receptor (EGFR) family consists of four members that belong to the ErbB lineage of proteins (ErbB1-4). These receptors consist of a glycosylated extracellular domain, a single hydrophobic transmembrane segment, and an intracellular portion with a juxtamembrane segment, a protein kinase domain, and a carboxyterminal tail. Seven ligands bind to EGFR including epi...
متن کاملTargeting the HER Family with Pan-HER Effectively Overcomes Resistance to Cetuximab.
Cetuximab, an antibody against the EGFR, has shown efficacy in treating head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer, and non-small cell lung cancer (NSCLC). Despite the clinical success of cetuximab, many patients do not respond to cetuximab. Furthermore, virtually all patients who do initially respond become refractory, highlighting both intrinsic and acquired r...
متن کاملArtemis: sequence visualization and annotation
SUMMARY Artemis is a DNA sequence visualization and annotation tool that allows the results of any analysis or sets of analyses to be viewed in the context of the sequence and its six-frame translation. Artemis is especially useful in analysing the compact genomes of bacteria, archaea and lower eukaryotes, and will cope with sequences of any size from small genes to whole genomes. It is impleme...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Graeco-Latina Brunensia
سال: 2016
ISSN: 1803-7402,2336-4424
DOI: 10.5817/glb2016-2-4